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  5. Tocris Bioscience™ BAY 299

Tocris Bioscience™ BAY 299
GREENER_CHOICE

Catalog No. 59705
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Quantity:
5 mg
25 mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

Potent and selective BRD1 and TAF1 inhibitor

BAY 299 is a potent and selective BRD1 and TAF1 inhibitor (IC50 values are 6-67 and 8-13 nM, respectively). Displays selectivity over other bromodomains (>30-fold over other members of the BRPF family; BRD9 and ATAD2; >300-fold over BRD4). Displays BRD1 and TAF1 inhibition in a NanoBRET cell assay. Inhibits binding of BRD1 and TAF1 to histone H4 (IC50 values are 575 nM and 0.9 μM, respectively) and histone H3.3 (IC50 values are 825 nM and 1.4 μM, respectively).

Specifications

Chemical Name or Material 6-(3-Hydroxypropyl)-2-(1,3,6-trimethyl-2-oxo-2,3-dihydro-1H-benzimidazol-5-yl)-1H-benzo[de]isoquinoline-1,3(2H)-dione
CAS 2080306-23-4
Assay Percent Range >98%
Quantity 5 mg
Molecular Formula C25H23N3O4
Formula Weight Observed MW: 429.47
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