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Tocris Bioscience™ BAY 390

Catalog No. 797810
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79-781-0 10 mg
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Catalog No. 79-781-0 Supplier Tocris Bioscience™ Supplier No. 7978/10
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Description

Potent and selective TRPA1 antagonist. Brain penetrant and orally bioavailable

BAY 390 is a potent and selective transient receptor potential ankyrin 1 (TRPA1) antagonist (IC50 values are 16, 63 and 82 nM for hTRPA1 FLIPR, rTRPA1 FLIPR and hTRPA1 Ephys, respectively). In vivo, BAY 390 exhibits efficacy in rat models of inflammatory and neuropathic pain. BAY 390 is orally bioavailable and brain penetrant. Suitable to use as an in vitro or in vivo probe to investigate the roles of TRPA1 in models of acute, inflammatory, and neuropathic pain.

Specifications

Chemical Name or Material (1R,2R)-2-[(4-Fluorophenyl)amino]-1-(trifluoromethyl)cyclohexanol
CAS 2741956-55-6
Quantity 10 mg
Target TRPA1 Blockers
Molecular Formula C13H15F4NO
Purity 0.98
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