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Tocris Bioscience™ BAY 593

Catalog No. RD81135
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RD81135 5 mg
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Catalog No. RD81135 Supplier Tocris Bioscience™ Supplier No. 8113/5
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Description

Geranylgeranyltransferase-I (GGTase-I) inhibitor

BAY 593 is a geranylgeranyltransferase-I (GGTase-I) inhibitor. Blocks activation of Rho-GTPases to inactivate YAP1/TAZ signaling. Dose-dependently inhibits growth of tumors in xenograft mouse models (IC50 values are 38.4 nM and 564 nM in MT-1080 and MDA-MB-231 cells respectively) and PXF 541 xenografts. Orally bioavailable and suitable for use in vivo.

Specifications

Chemical Name or Material (2R)-3,3,3-Trifluoro-2-methoxy-1-[(7R)-7-(2-methoxyphenyl)-3,9-diazaspiro[5.5]undec-3-yl]-2-phenyl-1-propanone hydrochloride
CAS 2413020-57-0
Quantity 5 mg
Target Other Transferase Inhibitors
Molecular Formula C26H31F3N2O3.HCl
Purity 98%
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