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  5. Tocris™ BAY 8002

Tocris™ BAY 8002

Catalog No. 681710
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Catalog No. Quantity
68-171-0 10 mg
68-175-0 50 mg
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Catalog No. 68-171-0 Supplier Tocris™ Supplier No. 6817/10
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Description

Potent dual MCT1/2 inhibitor; orally bioavailable

BAY 8002 is a potent dual MCT1/2 inhibitor (IC50 values are 3, 8, and 12 nM at rat (C6), human (DLD-1) and mouse (4T1) MCT1 respectively; IC50 values of human MCT1, MCT2, and MCT4 isoforms recombinantly expressed in X. laevis oocytes are 1, 5 and >500 nM, respectively); suppresses bidirectional lactate transport. Inhibits cellular SNARF-5 fluorescence change (IC50 = 85 nM) in MCT1-expressing DLD-1 cells. Arrests growth and increases intratumor lactate levels of Raji tumor xenografts in mice. Orally bioavailable.

Specifications

Quantity 10 mg
Molecular Formula C20H14ClNO5S
Formula Weight 415.85
Product Type Inhibitor
Purity 98%
Product Title
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