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  5. Tocris™ BAY 87-2243

Tocris™ BAY 87-2243
SDP

Catalog No. 698025 Shop All Novus Biologicals Products
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25 mg
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Catalog No. Quantity
69-802-5 25 mg
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Catalog No. 69-802-5 Supplier Tocris™ Supplier No. 6980/25

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Description

Mitochondrial complex I inhibitor

BAY 87-2243 is a mitochondrial complex I inhibitor. Exhibits no effect on mitochondrial complex III. Induces mitochondrial permeability transition pore (mPTP) opening, stimulates autophagosome formation and mitophagy, and increases ROS levels. Activates necroptotic and ferroptotic cell death. Also inhibits hypoxia-induced gene activation. Induces cell death in melanoma cell lines in vitro and exhibits antitumor activity in a mouse NSCLC xenograft model in vivo.

Specifications

Chemical Name or Material 1-Cyclopropyl-4-[4-[[5-methyl-3-[3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl]-1H-pyrazol-1-yl]methyl]-2-pyridinyl]piperazine
CAS 1227158-85-1
Quantity 25 mg
Molecular Formula C26H26F3N7O2
Purity 98%
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