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Tocris Bioscience™ BAY 876

Catalog No. 61995
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61-995 5 mg
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Catalog No. 61-995 Supplier Tocris Bioscience™ Supplier No. 6199/5
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Description

Potent and selective GLUT1 inhibitor

BAY 876 is a potent and selective GLUT1 inhibitor (IC50 = 2 nM) that displays selectivity for GLUT1 over GLUT2/3/4 (IC50 values are 10.8, 1.67 and 0.29 μM, respectively). BAY 876 induces cell death in hypoxic conditions in vitro and inhibits glucose uptake by Hela-MaTu cells. In ovarian cancer, BAY 876 reduces glycolysis rates and ATP production and inhibits proliferation in vitro and in vivo. This compound is cell permeable and orally bioavailable.

Specifications

Chemical Name or Material N4-[1-[(4-Cyanophenyl)methyl]-5-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]-7-fluoro-2,4-quinolinedicarboxamide
CAS 1799753-84-6
Quantity 5 mg
Molecular Formula C24H16F4N6O2
Purity 98%
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