Invitrogen™ BBS10 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA597161

Catalog No. PIPA597161

Description

Immunogen sequence: AENKDALEKT QTYLKVHSNL VIPDVELETY IPYSTPTLTP TDTFQTVETL TCLSLERNRL TDYYEPLLKN NSTAYSTRGN RIEISYENLQ VTNITRKGSM LPVSCKLPNM GTSQSYLSSS MPAGCVLPVG GNFEILLHYY LLNYAKKCHQ SEETMVSMII ANALLGIPKV LYKSKTGKYS FPHTYIRAVH ALQTNQPLVS SQTGLESVMG KYQLLTSVLQ CLTKILTIDM VITVKRHPQK VHNQDSEDEL; Positive Samples: A-549, A-431, HT-1080, HeLa, HepG2, Mouse liver; Cellular Location: Cell projection, cilium.

BBS10 is a member of the Bardet-Biedl syndrome (BBS) gene family. Bardet-Biedl syndrome is an autosomal recessive disorder characterized by progressive retinal degeneration, obesity, polydactyly, renal malformation and mental retardation. The proteins encoded by BBS gene family members are structurally diverse and the similar phenotypes exhibited by mutations in BBS gene family members is likely due to their shared roles in cilia formation and function. Many BBS proteins localize to the basal bodies, ciliary axonemes, and pericentriolar regions of cells. BBS proteins may also be involved in intracellular trafficking via microtubule-related transport. The protein encoded by this gene is likely not a ciliary protein but rather has distant sequence homology to type II chaperonins. As a molecular chaperone, this protein may affect the folding or stability of other ciliary or basal body proteins. Inhibition of this protein's expression impairs ciliogenesis in preadipocytes.

Specifications

• Antigen: BBS10
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: BBS10
• Gene Alias: 1300007O09Rik; AI452285; Bardet-Biedl syndrome 10; Bardet-Biedl syndrome 10 (human); Bardet-Biedl syndrome 10 protein; Bardet-Biedl syndrome 10 protein homolog; Bbs10; C12orf58; RGD1560748; si:dkey-30c15.16
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 71769, 79738
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 1.78 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: Q8TAM1, Q9DBI2
• Gene Symbols: BBS10
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 474-723 of human BBS10 (NP_0789613).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov