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Invitrogen™ BBS10 Polyclonal Antibody
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Catalog No. PIPA597161
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100 μL
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PIPA597161 100 μL
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Catalog No. PIPA597161 Supplier Invitrogen™ Supplier No. PA597161
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: AENKDALEKT QTYLKVHSNL VIPDVELETY IPYSTPTLTP TDTFQTVETL TCLSLERNRL TDYYEPLLKN NSTAYSTRGN RIEISYENLQ VTNITRKGSM LPVSCKLPNM GTSQSYLSSS MPAGCVLPVG GNFEILLHYY LLNYAKKCHQ SEETMVSMII ANALLGIPKV LYKSKTGKYS FPHTYIRAVH ALQTNQPLVS SQTGLESVMG KYQLLTSVLQ CLTKILTIDM VITVKRHPQK VHNQDSEDEL; Positive Samples: A-549, A-431, HT-1080, HeLa, HepG2, Mouse liver; Cellular Location: Cell projection, cilium.

BBS10 is a member of the Bardet-Biedl syndrome (BBS) gene family. Bardet-Biedl syndrome is an autosomal recessive disorder characterized by progressive retinal degeneration, obesity, polydactyly, renal malformation and mental retardation. The proteins encoded by BBS gene family members are structurally diverse and the similar phenotypes exhibited by mutations in BBS gene family members is likely due to their shared roles in cilia formation and function. Many BBS proteins localize to the basal bodies, ciliary axonemes, and pericentriolar regions of cells. BBS proteins may also be involved in intracellular trafficking via microtubule-related transport. The protein encoded by this gene is likely not a ciliary protein but rather has distant sequence homology to type II chaperonins. As a molecular chaperone, this protein may affect the folding or stability of other ciliary or basal body proteins. Inhibition of this protein's expression impairs ciliogenesis in preadipocytes.
TRUSTED_SUSTAINABILITY

Specifications

Antigen BBS10
Applications ELISA, Western Blot
Classification Polyclonal
Concentration 1.78 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene BBS10
Gene Accession No. Q8TAM1, Q9DBI2
Gene Alias 1300007O09Rik; AI452285; Bardet-Biedl syndrome 10; Bardet-Biedl syndrome 10 (human); Bardet-Biedl syndrome 10 protein; Bardet-Biedl syndrome 10 protein homolog; Bbs10; C12orf58; RGD1560748; si:dkey-30c15.16
Gene Symbols BBS10
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 474-723 of human BBS10 (NP_0789613).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 71769, 79738
Target Species Human, Mouse
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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