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Invitrogen™ BBS5 Polyclonal Antibody
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Catalog No. PIPA5104312
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PIPA5104312 100 μL
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Catalog No. PIPA5104312 Supplier Invitrogen™ Supplier No. PA5104312
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total BBS5.

The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for BBSome complex ciliary localization but not for the proper complex assembly.
TRUSTED_SUSTAINABILITY

Specifications

Antigen BBS5
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene BBS5
Gene Accession No. Q8N3I7, Q9CZQ9
Gene Alias 1700049I01Rik; 2700023J09Rik; Bardet-Biedl syndrome 5; Bardet-Biedl syndrome 5 (human); Bardet-Biedl syndrome 5 homolog; Bardet-Biedl syndrome 5 protein; Bardet-Biedl syndrome 5 protein homolog; Bbs5; novel DUF1448 protein
Gene Symbols BBS5
Host Species Rabbit
Immunogen A synthesized peptide derived from human BBS5(Accession Q8N3I7), corresponding to amino acid residues T280-G330.
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 129880, 362142, 72569
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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