Invitrogen™ BBS5 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5104312

Catalog No. PIPA5104312

Description

Antibody detects endogenous levels of total BBS5.

The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for BBSome complex ciliary localization but not for the proper complex assembly.

Specifications

• Antigen: BBS5
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: BBS5
• Gene Alias: 1700049I01Rik; 2700023J09Rik; Bardet-Biedl syndrome 5; Bardet-Biedl syndrome 5 (human); Bardet-Biedl syndrome 5 homolog; Bardet-Biedl syndrome 5 protein; Bardet-Biedl syndrome 5 protein homolog; Bbs5; novel DUF1448 protein
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 129880, 362142, 72569
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: Q8N3I7, Q9CZQ9
• Gene Symbols: BBS5
• Immunogen: A synthesized peptide derived from human BBS5(Accession Q8N3I7), corresponding to amino acid residues T280-G330.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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