Invitrogen™ BBS9 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5100220

Catalog No. PIPA5100220

Description

Antibody detects endogenous levels of total BBS9.

The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. Required for proper BBSome complex assembly and its ciliary localization.

Specifications

• Antigen: BBS9
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: BBS9
• Gene Alias: B1; Bardet-Biedl syndrome 9; Bardet-Biedl syndrome 9 (human); bardet-Biedl syndrome 9 protein; Bardet-Biedl syndrome 9 protein homolog; BBS9; C18; D1; E130103I17Rik; EST 3159894; parathyroid hormone-responsive B1 gene protein; Parathyroid hormone-responsive B1 gene protein homolog; protein PTHB1; PTHB1; PTH-responsive osteosarcoma B1 protein; RGD1308472
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 27241, 319845
• Content And Storage: -20°C
• Form: Liquid

• Applications: Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: Q3SYG4, Q811G0
• Gene Symbols: BBS9
• Immunogen: A synthesized peptide derived from human BBS9(Accession Q3SYG4), corresponding to amino acid residues G767-D817.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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