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BBS9 Rabbit anti-Human, Mouse, Polyclonal, Proteintech
SDP

Catalog No. 501729467 Shop All Proteintech Group Inc Products
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50-172-9467 150 μL
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Catalog No. 50-172-9467 Supplier Proteintech Group Inc Supplier No. 144601AP150UL
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Description

Rabbit Polyclonal Antibody

The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. Required for proper BBSome complex assembly and its ciliary localization.

Specifications

Antigen BBS9
Applications Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Classification Polyclonal
Concentration 0.37 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene BBS9
Gene Accession No. Q3SYG4, Q811G0
Gene Alias B1, Bardet Biedl syndrome 9, BBS9, C18, D1, Protein PTHB1, PTHB1
Gene Symbols BBS9
Host Species Rabbit
Immunogen BBS9 Fusion Protein Ag5665
Purification Method Antigen Affinity Chromatography
Quantity 150 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 27241, 319845
Target Species Human, Mouse
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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