Invitrogen™ BCDIN3D Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA558979

Catalog No. PIPA558979

Description

Immunogen sequence: EPQPWKCYRA AARRLRKLGL HDFDHFHSLA IRGDMPNQIV QILTQDHGME LICCFGNTSW DRSLLLFRAK QTIETHPIPE SLIEKGKEKN RLSFQKQ Highest antigen sequence identity to the following orthologs: Mouse - 73%, Rat - 73%.

O-methyltransferase that specifically monomethylates 5'- monophosphate of cytoplasmic histidyl tRNA (tRNA(His)), acting as a capping enzyme by protecting tRNA(His) from cleavage by DICER1. Also able, with less efficiently, to methylate the 5' monophosphate of a subset of pre- miRNAs, acting as a negative regulator of miRNA processing. The 5' monophosphate of pre-miRNAs is recognized by DICER1 and is required for pre-miRNAs processing: methylation at this position reduces the processing of pre-miRNAs by DICER1. Was also reported to mediate dimethylation of pre-miR-145; however dimethylation cannot be reproduced by another group which observes a monomethylation of pre-miR-145.

Specifications

• Antigen: BCDIN3D
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: BCDIN3D
• Gene Alias: BCDIN3 domain containing RNA methyltransfease; BCDIN3 domain containing RNA methyltransferase; BCDIN3 domain-containing protein; BCDIN3D; pre-miRNA 5'-monophosphate methyltransferase; probable methyltransferase BCDIN3D; RNA 5'-monophosphate methyltransferase
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 144233
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Immunocytochemistry
• Concentration: 0.1 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q7Z5W3
• Gene Symbols: BCDIN3D
• Immunogen: Recombinant protein corresponding to Human BCDIN3D. Recombinant protein control fragment (Product #RP-97875).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG