Bcl-10 Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Supplier:  Thermo Scientific PA585359

Catalog No. PIPA585359

Description

Keep as concentrated solution. Predicted reactivity: Mouse (95%), Rat (96%), Pig (96%), Rhesus Monkey (99%), Bovine (99%). Positive Control: Jurkat, Neuro2A, GL261, C8D30. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

BCL-10 is an N-terminal CARD (Caspase Recruitment Domain) containing protein that is involved in the adaptive immune response. It promotes apoptosis, pro-caspase-9 maturation, and activation of NF-kappa-B via NIK and IKK. BCL-10 is also an adapter protein between upstream TNFR1-TRADD-RIP complex and the downstream NIK-IKK-IKAP complex. It is a substrate for MALT1. Mutations in the gene can lead to Immmunodeficiency 37 or Lymphoma, mucosa-associated lymphoid type.

Specifications

• Antigen: Bcl-10
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: BCL10
• Gene Alias: AI132454, B cell CLL/lymphoma 10, B cell leukemia/lymphoma 10, B-cell CLL/lymphoma 10, B-cell leukemia/lymphoma 10, B-cell lymphoma/leukemia 10, BCL10, Bcl-10, BCL10 immune signaling adaptor, C81403, CARD containing molecule enhancing NF-kB, CARD-containing apoptotic signaling protein, CARD-containing molecule enhancing NF-kappa-B, CARD-containing proapoptotic protein, CARD-like apoptotic protein, CARMEN, caspase-recruiting domain-containing protein, cCARMEN, cE10, c-E10, CED-3/ICH-1 prodomain homologous E10-like regulator, cellular homolog of vCARMEN, Cellular-E10, CIPER, Clap, hCLAP, IMD37, Mamm, mammalian CARD-containing adapter molecule E10, mCIPER, mCLAP, mE10, OTTHUMP00000011647, OTTHUMP00000036080, RCD, RP11-234D19.2, R-RCD1
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 12042, 83477, 8915
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 1% BSA, 20% glycerol and 0.01% thimerosal, pH 7
• Gene Accession No.: O95999, Q9QYN5, Q9Z0H7
• Gene Symbols: BCL10
• Immunogen: Recombinant protein encompassing a sequence within the center region of human BCL10.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG