Bcl 2 like 13 protein Rabbit anti-Human, Polyclonal, Bioss

Catalog No.	Quantity
50-198-7848	100 μL

Catalog No. 50-198-7848 Supplier Bioss Supplier No. BS7584R

Description

Rabbit Polyclonal Antibody

Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer. Members of the Bcl-2 family are known to be critical regulators of this process. These proteins are characterized by the presence of several conserved motifs termed Bcl-2 homology (BH) domains. A novel, widely expressed member termed Bcl-rambo was recently identified. This protein is localized to mitochondria in mammalian cells and its overexpression induces apoptosis which could be blocked by co-expression of inhibitor of apoptosis proteins (IAPs) such as XIAP, cIAP1, and cIAP2. Bcl-rambo shows overall homology to the anti-apoptotic members containing BH motifs, but unlike Bcl-2, the C-terminal membrane anchor of Bcl-rambo is preceded by a unique 250 amino acid insertion. This region by itself can induce apoptosis more efficiently than the Bcl-2 homology regions, suggesting that Bcl-rambo may be important other pro-apoptotic pathways.

Specifications

• Antigen: Bcl 2 like 13 protein
• Applications: Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
• Classification: Polyclonal
• Concentration: 1 μg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
• Gene: BCL2L13
• Gene Accession No.: Q9BXK5
• Gene Alias: BCL2 like 13; Bcl2l13; Bcl2-L-13; BCL2-like 13 (apoptosis facilitator); Bcl-2-like protein 13; Bcl-rambo; CD003; E430016C20Rik; Mil1; Mil-1; mitochondria located 1 homolog; Protein Mil1
• Gene Symbols: BCL2L13
• Host Species: Rabbit
• Immunogen: KLH conjugated synthetic peptide derived from human Bcl rambo/Bcl 2 like 13 protein .
• Purification Method: Protein A
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 23786
• Target Species: Human
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG