Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
  1. Home
  2. Products
  3. Antibodies
  4. Primary Antibodies
  5. All Primary Antibodies
  6. PIMA126233

Invitrogen™ Bcl-2 Monoclonal Antibody (124)
GREENER_CHOICE

Catalog No. PIMA126233
Change view
Click to view available options
Quantity:
250 μL
1 product options available for selection
Product selection table with 1 available options. Use arrow keys to navigate and Enter or Space to select.
Catalog No. Quantity
PIMA126233 250 μL
Use arrow keys to navigate between rows. Press Enter or Space to select a product option. 1 options available.
1 options
Catalog No. PIMA126233 Supplier Invitrogen™ Supplier No. MA126233
Add to Cart
Add to Cart

Description

Mouse Monoclonal Antibody

Positive control of Tonsil or human lung cell line suggested. This antibody works well with B5 or Bouin's fixed tissues. Formalin fixed tissues may give inconsistent results.

BCL-2 is a key regulator of apoptosis that functions to either inhibit or promote cell death. The BCL-2 family members are also characterized by dimerizing to further modulate apoptosis. Bag1, for example, has been found to form a heterodimer with BCL-2 resulting in the enhancement of the anti-apoptotic effect of BCL-2. Bax and Bak have been shown to play a critical role in cytochrome c release from mitochondria and thus initiate apoptosis. Bax exerts a pro-apoptotic rather than an anti-apoptotic effect on cells. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. In most follicular lymphomas, neoplastic germinal centers express high levels of BCL-2 alpha protein, whereas the normal or hyperplastic germinal centers are negative. Two transcript variants of BCL-2, produced by alternate splicing, differ in their C-terminal ends. The overexpression of BCL-2 has been linked to human cancers such as B-cell lymphoma and prostate cancer.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Bcl-2
Applications Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Classification Monoclonal
Clone 124
Concentration Conc. Not Determined
Conjugate Unconjugated
Formulation Tissue culture supernatant with 0.09% sodium azide
Gene Bcl2
Gene Accession No. P10415
Gene Alias apoptosis regulator Bcl-2; AW986256; B cell leukemia/lymphoma 2; B cell lymphoma 2 associated oncogene; B-cell CLL/lymphoma 2; B-cell leukemia/lymphoma 2; Bcl 2; BCL2; bcl-2; BCL2 apoptosis regulator; Bcl-2 protein; BCL2, apoptosis regulator; Bcl2-like protein; C430015F12Rik; D630044D05Rik; D830018M01Rik; OTTHUMP00000163680; PPP1R50; protein phosphatase 1, regulatory subunit 50
Gene Symbols Bcl2
Host Species Mouse
Immunogen Recombinant Bcl-2 peptide sequence comprising 41-54 amino acids of Bcl-2 oncoprotein.
Quantity 250 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 596
Target Species Human
Content And Storage 4°C
Product Type Antibody
Form Liquid
Isotype IgG1
Show More Show Less
Product Title
Select an issue

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.