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Bcl-2 Antibody (BCL2/2210R), DyLight 350, Novus Biologicals™
SDP

Catalog No. NB009005 Shop All R&D Systems Products
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NB009005 0.1 mL
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Catalog No. NB009005 Supplier Novus Biologicals Supplier No. NBP275764UV
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Description

Rabbit Monoclonal Antibody

Bcl-2 Monoclonal specifically detects Bcl-2 in Human samples. It is validated for Western Blot, Immunohistochemistry, Immunohistochemistry-Paraffin.

Specifications

Antigen Bcl-2
Applications Western Blot, Immunohistochemistry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin)
Classification Monoclonal
Clone BCL2/2210R
Conjugate DyLight 350
Dilution Western Blot, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry-Paraffin
Formulation 50mM Sodium Borate with 0.05% Sodium Azide
Gene Alias apoptosis regulator Bcl-2, B-cell CLL/lymphoma 2, Bcl-2
Gene Symbols BCL2
Host Species Rabbit
Immunogen Recombinant full-length human bcl-2 protein (Uniprot: P10415)
Purification Method Protein A or G purified
Quantity 0.1 mL
Regulatory Status RUO
Research Discipline Apoptosis, Autophagy, Biologically Active Proteins, Cancer, Cellular Markers, Mitochondrial Mediated Pathway, Mitophagy, Oncogenes, Phospho Specific, Tumor Suppressors
Primary or Secondary Primary
Test Specificity This antibody recognizes a protein of 25-26kDa, identified as the Bcl-2 lpha oncoprotein. It shows no cross-reaction with Bcl-x or Bax protein. Expression of Bcl-2 lpha oncoprotein inhibits the programmed cell death (apoptosis). In most follicular lymphomas, neoplastic germinal centers express high levels of Bcl-2 lpha protein, whereas the normal or hyperplastic germinal centers are negative. Consequently, this antibody is valuable when distinguishing between reactive and neoplastic follicular proliferation in lymph node biopsies. It may also be used in distinguishing between those follicular lymphomas that express Bcl-2 protein and the small number in which the neoplastic cells are Bcl-2 negative.
Target Species Human
Content And Storage Store at 4°C in the dark.
Isotype IgG
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