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Bcl-6 Antibody (BCL6/1475), DyLight 680, Novus Biologicals™
SDP

Catalog No. NBP259597FR Shop All R&D Systems Products
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NBP259597FR 100 μL
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Catalog No. NBP259597FR Supplier Novus Biologicals Supplier No. NBP259597FR
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Description

Mouse Monoclonal Antibody

Bcl-6 Monoclonal specifically detects Bcl-6 in Human samples. It is validated for Western Blot, Flow Cytometry.

Specifications

Antigen Bcl-6
Applications Western Blot, Flow Cytometry, Immunocytochemistry, Immunofluorescence
Classification Monoclonal
Clone BCL6/1475
Conjugate DyLight 680
Dilution Western Blot, Flow Cytometry, Immunocytochemistry/Immunofluorescence
Formulation 50mM Sodium Borate with 0.05% Sodium Azide
Gene Alias B-cell CLL/lymphoma 6, B-cell lymphoma 6 protein transcript, BCL-5, BCL5B-cell lymphoma 5 protein, BCL-6, BCL6A, cys-his2 zinc finger transcription factor, LAZ3ZBTB27B-cell lymphoma 6 protein, lymphoma-associated zinc finger gene on chromosome 3, Protein LAZ-3, Zinc finger and BTB domain-containing protein 27, Zinc finger protein 51ZNF51, zinc finger transcription factor BCL6S
Gene Symbols BCL6
Host Species Mouse
Immunogen Recombinant human bcl-6 protein fragment (around aa256-389) (exact sequence is proprietary) (Uniprot: P41182)
Purification Method Protein A or G purified
Quantity 100 μL
Regulatory Status RUO
Research Discipline Cancer, Cell Cycle and Replication, Tumor Suppressors
Primary or Secondary Primary
Gene ID (Entrez) 604
Test Specificity The specificity of this monoclonal antibody to its intended target was validated by HuProtTM Array, containing more than 19,000, full-length human proteins. Recognizes a protein of 95kDa, which is identified as Bcl-6. Antibody to bcl-6 is helpful in a number of diagnostic settings: (1) In the differential diagnosis of small B-cell lymphoma. Follicular lymphoma will show bcl-6 (and CD10) positivity whereas other small B-cell lymphomas are usually negative. (2) Bcl-6 is an important prognostic marker in diffuse large B-cell lymphomas (DLBCL), where CD10, bcl-6 and MUM1/IRF4 are used to identify germinal center and activated B-cell phenotypes. (3) Bcl-6 can be valuable in distinguishing classical Hodgkin lymphoma from nodular lymphocyte predominant Hodgkin lymphoma (NLPHL). The Reed-Sternberg cells of classical Hodgkin lymphoma are bcl-6 negative whereas the large ('LH') cells of NLPHL are bcl-6 positive. In contrast, anti-Bcl-6 rarely stains mantle-cell lymphoma and MALT lymphoma.
Target Species Human
Content And Storage Store at 4C in the dark.
Form Purified
Isotype IgG1 κ
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For Research Use Only (RUO)

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