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Invitrogen™ Bcl-rambo Polyclonal Antibody
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Catalog No. PIPA583173
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100 μL
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PIPA583173 100 μL
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Catalog No. PIPA583173 Supplier Invitrogen™ Supplier No. PA583173
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: QFGVTYLEDY SAEYIIQQGG WGTVFSLESE EEEYPGITAE DSNDIYILPS DNSGQVSPPE SPTVTTSWQS E Highest antigen sequence indentity to the following orthologs: Mouse - 89%, Rat - 90%.

Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer. Members of the Bcl-2 family are known to be critical regulators of this process. These proteins are characterized by the presence of several conserved motifs termed Bcl-2 homology (BH) domains. A novel, widely expressed member termed Bcl-rambo was recently identified. This protein is localized to mitochondria in mammalian cells and its overexpression induces apoptosis which could be blocked by co-expression of inhibitor of apoptosis proteins (IAPs) such as XIAP, cIAP1, and cIAP2. Bcl-rambo shows overall homology to the anti-apoptotic members containing BH motifs, but unlike Bcl-2, the C-terminal membrane anchor of Bcl-rambo is preceded by a unique 250 amino acid insertion. This region by itself can induce apoptosis more efficiently than the Bcl-2 homology regions, suggesting that Bcl-rambo may be important other pro-apoptotic pathways.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Bcl-rambo
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 0.05 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene BCL2L13
Gene Accession No. Q9BXK5
Gene Alias BCL2 like 13; BCL2L13; Bcl2-L-13; BCL2-like 13 (apoptosis facilitator); bcl-2-like protein 13; Bcl-rambo; CD003; E430016C20Rik; MIL1; Mil-1; mitochondria located 1 homolog; protein Mil1
Gene Symbols BCL2L13
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human BCL2L13. Recombinant protein control fragment (Product #RP-95343).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 23786
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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