Invitrogen™ Bcl-rambo Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5104393

Catalog No. PIPA5104393

Description

Antibody detects endogenous levels of total BCL2L13.

Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer. Members of the Bcl-2 family are known to be critical regulators of this process. These proteins are characterized by the presence of several conserved motifs termed Bcl-2 homology (BH) domains. A novel, widely expressed member termed Bcl-rambo was recently identified. This protein is localized to mitochondria in mammalian cells and its overexpression induces apoptosis which could be blocked by co-expression of inhibitor of apoptosis proteins (IAPs) such as XIAP, cIAP1, and cIAP2. Bcl-rambo shows overall homology to the anti-apoptotic members containing BH motifs, but unlike Bcl-2, the C-terminal membrane anchor of Bcl-rambo is preceded by a unique 250 amino acid insertion. This region by itself can induce apoptosis more efficiently than the Bcl-2 homology regions, suggesting that Bcl-rambo may be important other pro-apoptotic pathways.

Specifications

• Antigen: Bcl-rambo
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: BCL2L13
• Gene Alias: BCL2 like 13; BCL2L13; Bcl2-L-13; BCL2-like 13 (apoptosis facilitator); bcl-2-like protein 13; Bcl-rambo; CD003; E430016C20Rik; MIL1; Mil-1; mitochondria located 1 homolog; protein Mil1
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 23786, 312682, 94044
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: P59017, Q9BXK5
• Gene Symbols: BCL2L13
• Immunogen: A synthesized peptide derived from human BCL2L13(Accession Q9BXK5), corresponding to amino acid residues S208-A258.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov