Invitrogen™ Bcl-xL Monoclonal Antibody (7B2.5), PE

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA528638

Catalog No. PIMA528638

Description

Bcl-xL Monoclonal Antibody for Flow

BCL-XL is a part of the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. BCL-XL is located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential and controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Two alternatively spliced transcript variants, which encode distinct isoforms, have been reported. The longer isoform acts as an apoptotic inhibitor and the shorter form acts as an apoptotic activator.

Specifications

• Antigen: Bcl-xL
• Classification: Monoclonal
• Concentration: 0.1 mg/mL
• Formulation: PBS with proprietary stabilizer and <0.1% sodium azide; pH 7.5
• Gene Accession No.: P53563, Q07817, Q64373
• Gene Symbols: BCL2L1
• Immunogen: Recombinant human Bcl-xS.
• Quantity: 1 mL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat, Rhesus Macaque
• Product Type: Antibody
• Isotype: IgG3 κ

• Applications: Flow Cytometry
• Clone: 7B2.5
• Conjugate: PE
• Gene: BCL2L1
• Gene Alias: anti-apoptosis regulatory protein; apoptosis regulator Bcl-X; B cell lymphoma 2 like; B cell lymphoma like X; B-cell leukemia/lymphoma x; Bcl(X)L; BCL2 like 1; Bcl2l; BCL2L1; bcl2-L-1; BCL2-like 1; Bcl-2-like protein 1; BCLX; bcl-x; BCLXL; Bcl-XL; BCL-XL/S; BCLXS; bcl-xS; Blc2l; DKFZp781P2092; EGK_02534; OTTHUMP00000030550; OTTHUMP00000030552; OTTHUMP00000030555; OTTHUMP00000030556; OTTHUMP00000030557; PPP1R52; protein phosphatase 1, regulatory subunit 52; RP5-857M17.3
• Host Species: Mouse
• Purification Method: Purified
• Regulatory Status: RUO
• Gene ID (Entrez): 12048, 24888, 598, 713035
• Content And Storage: 4°C, store in dark, DO NOT FREEZE!
• Form: Liquid

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov