Bcl-XL Mouse anti-Human, Clone: OTI4A9, liquid, TrueMAB™

Mouse Monoclonal Antibody

Supplier:  OriGene TA500097S

Catalog No. 50-167-1397

Description

BCL-XL is a part of the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. BCL-XL is located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential and controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Two alternatively spliced transcript variants, which encode distinct isoforms, have been reported. The longer isoform acts as an apoptotic inhibitor and the shorter form acts as an apoptotic activator.

Specifications

• Antigen: Bcl-XL
• Classification: Monoclonal
• Concentration: 0.25 mg/mL
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
• Gene Accession No.: Q07817
• Gene Symbols: BCL2L1
• Immunogen: Recombit fragment expressed in E.coli corresponding to amino acids 1-212 of human Bcl-XL
• Quantity: 30 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG2a

• Applications: Immunocytochemistry, Immunofluorescence, Western Blot
• Clone: OTI4A9
• Conjugate: Unconjugated
• Gene: BCL2L1
• Gene Alias: BCL-XL/S, BCL2L, BCLX, Bcl-X, PPP1R52
• Host Species: Mouse
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 598
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid