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Bcl-XL Mouse anti-Human, Clone: OTI4A9, liquid, TrueMAB™

Mouse Monoclonal Antibody
Supplier: OriGene TA500097S

Description
BCL-XL is a part of the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. BCL-XL is located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential and controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Two alternatively spliced transcript variants, which encode distinct isoforms, have been reported. The longer isoform acts as an apoptotic inhibitor and the shorter form acts as an apoptotic activator.Specifications
Bcl-XL | |
Monoclonal | |
0.25 mg/mL | |
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide | |
Q07817 | |
BCL2L1 | |
Recombit fragment expressed in E.coli corresponding to amino acids 1-212 of human Bcl-XL | |
30 μL | |
Primary | |
Human | |
Antibody | |
IgG2a |
Immunocytochemistry, Immunofluorescence, Western Blot | |
OTI4A9 | |
Unconjugated | |
BCL2L1 | |
BCL-XL/S, BCL2L, BCLX, Bcl-X, PPP1R52 | |
Mouse | |
Protein A | |
RUO | |
598 | |
-20° C, Avoid Freeze/Thaw Cycles | |
Liquid |
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