Bcl-XL Mouse anti-Human, Clone: OTI4A9, liquid, TrueMAB™

Catalog No.	Quantity
50-167-1397	30 μL

Catalog No. 50-167-1397 Supplier OriGene Supplier No. TA500097S

Description

Mouse Monoclonal Antibody

BCL-XL is a part of the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. BCL-XL is located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential and controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Two alternatively spliced transcript variants, which encode distinct isoforms, have been reported. The longer isoform acts as an apoptotic inhibitor and the shorter form acts as an apoptotic activator.

Specifications

• Antigen: Bcl-XL
• Applications: Immunocytochemistry, Immunofluorescence, Western Blot
• Classification: Monoclonal
• Clone: OTI4A9
• Concentration: 0.25 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
• Gene: BCL2L1
• Gene Accession No.: Q07817
• Gene Alias: BCL-XL/S, BCL2L, BCLX, Bcl-X, PPP1R52
• Gene Symbols: BCL2L1
• Host Species: Mouse
• Immunogen: Recombit fragment expressed in E.coli corresponding to amino acids 1-212 of human Bcl-XL
• Purification Method: Protein A
• Quantity: 30 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 598
• Target Species: Human
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG2a