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Bcl-XL Rabbit anti-Human, Clone: 12C5, Bioss
SDP

Catalog No. 501989529
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100 μL
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50-198-9529 100 μL
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Catalog No. 50-198-9529 Supplier Bioss Supplier No. BSM52024R
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Description

Rabbit Monoclonal Antibody

BCL-XL is a part of the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. BCL-XL is located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential and controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Two alternatively spliced transcript variants, which encode distinct isoforms, have been reported. The longer isoform acts as an apoptotic inhibitor and the shorter form acts as an apoptotic activator.

Specifications

Antigen Bcl-XL
Applications Immunofluorescence, Immunohistochemistry (Paraffin)
Classification Monoclonal
Clone 12C5
Concentration 1 μg/mL
Conjugate Unconjugated
Formulation TBS with 1% BSA, 40% glycerol and 0.05% sodium azide; pH
Gene BCL2L1
Gene Accession No. Q07817
Gene Alias anti-apoptosis regulatory protein; Apoptosis regulator Bcl-X; B cell lymphoma 2 like; B cell lymphoma like X; B-cell leukemia/lymphoma x; Bcl(X)L; BCL2 like 1; Bcl2l; Bcl2l1; Bcl2-L-1; BCL2-like 1; Bcl-2-like protein 1; BCLX; bcl-X; BCLXL; Bcl-XL; BCL-XL/S; BCLXS; bcl-xS; Blc2l; DKFZp781P2092; EGK_02534; OTTHUMP00000030550; OTTHUMP00000030552; OTTHUMP00000030555; OTTHUMP00000030556; OTTHUMP00000030557; PPP1R52; protein phosphatase 1, regulatory subunit 52; RP5-857M17.3
Gene Symbols BCL2L1
Host Species Rabbit
Immunogen Recombinant human Bcl-XL protein, around 1-100aa.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 598
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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