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Invitrogen™ Bcl-XS Polyclonal Antibody
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Catalog No. PIPA578864
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100 μg
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PIPA578864 100 μg
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Catalog No. PIPA578864 Supplier Invitrogen™ Supplier No. PA578864
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Description

Rabbit Polyclonal Antibody

Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 μg/mL. Positive Control - WB: HELA whole cell, PC-12 whole cell. IHC: Human Colon Cancer Tissue.

The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Two alternatively spliced transcript variants, which encode distinct isoforms, have been reported. The longer isoform acts as an apoptotic inhibitor and the shorter form acts as an apoptotic activator.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Bcl-XS
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 500 μg/mL
Conjugate Unconjugated
Formulation PBS with 5mg BSA and 0.05mg sodium azide, 0.05mg thimerosal
Gene Bcl2l1
Gene Accession No. P53563, Q07817, Q64373
Gene Alias anti-apoptosis regulatory protein; apoptosis regulator Bcl-X; B cell lymphoma 2 like; B cell lymphoma like X; B-cell leukemia/lymphoma x; Bcl(X)L; BCL2 like 1; BCL2L; BCL2L1; bcl2-L-1; BCL2-like 1; Bcl-2-like protein 1; BCLX; bcl-x; BCLXL; Bcl-xl; BCL-XL/S; BCLXS; bcl-xS; Blc2l; PPP1R52; protein phosphatase 1, regulatory subunit 52
Gene Symbols Bcl2l1
Host Species Rabbit
Immunogen A synthetic peptide corresponding to a sequence in the middle region of human Bcl-XS (120-130aa YQSFEQDTFVE).
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 12048, 24888, 598
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Lyophilized
Isotype IgG
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