Learn More
BCL2 Mouse anti-Human, Clone: OTI3H10, lyophilized, TrueMAB™

Mouse Monoclonal Antibody
Supplier: OriGene CF806592

Description
Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO
BCL-2 is a key regulator of apoptosis that functions to either inhibit or promote cell death. The BCL-2 family members are also characterized by dimerizing to further modulate apoptosis. Bag1, for example, has been found to form a heterodimer with BCL-2 resulting in the enhancement of the anti-apoptotic effect of BCL-2. Bax and Bak have been shown to play a critical role in cytochrome c release from mitochondria and thus initiate apoptosis. Bax exerts a pro-apoptotic rather than an anti-apoptotic effect on cells. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. In most follicular lymphomas, neoplastic germinal centers express high levels of BCL-2 alpha protein, whereas the normal or hyperplastic germinal centers are negative. Two transcript variants of BCL-2, produced by alternate splicing, differ in their C-terminal ends. The overexpression of BCL-2 has been linked to human cancers such as B-cell lymphoma and prostate cancer.Specifications
BCL2 | |
Monoclonal | |
Unconjugated | |
BCL2 | |
Bcl-2, PPP1R50 | |
Mouse | |
Affinity Chromatography | |
RUO | |
596 | |
-20° C, Avoid Freeze/Thaw Cycles | |
Lyophilized |
Immunohistochemistry (Paraffin), Western Blot | |
OTI3H10 | |
PBS with 8% trehalose and no preservative; pH 7.3 | |
P10415 | |
BCL2 | |
Full length human recombit protein of human BCL2 produced in HEK293T cell. | |
100 μg | |
Primary | |
Human | |
Antibody | |
IgG2b |
The Fisher Scientific Encompass Program offers items which are not part of our distribution portfolio. These products typically do not have pictures or detailed descriptions. However, we are committed to improving your shopping experience. Please use the form below to provide feedback related to the content on this product.