Invitrogen™ BCL2A1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA520269

Catalog No. PIPA520269

Description

Despite the predicted molecular weight, Bfl-1 often migrates at a higher molecular weight in SDS-PAGE, presumably due to post-translational modifications. A suggested positive control is mouse kidney tissue lysate. PA5-20269 can be used with blocking peptide PEP-0384.

Bcl-2 related Protein A1 is a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators that are involved in a wide variety of cellular activities such as embryonic development, homeostasis and tumorigenesis. The protein encoded by this gene is able to reduce the release of pro-apoptotic cytochrome c from mitochondria and block caspase activation. This gene is a direct transcription target of NF-kappa B in response to inflammatory mediators, and has been shown to be up-regulated by different extracellular signals, such as granulocyte-macrophage colony-stimulating factor (GM-CSF), CD40, phorbol ester and inflammatory cytokine TNF and IL-1, which suggests a cytoprotective function that is essential for lymphocyte activation as well as cell survival.

Specifications

• Antigen: BCL2A1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: BCL2A1
• Gene Alias: A1; A1-A; ACC1; ACC-1; ACC2; ACC-2; B cell leukemia/lymphoma 2 related protein A1a; BB218357; B-cell leukemia/lymphoma 2 related protein A1; B-cell leukemia/lymphoma 2 related protein A1a; B-cell leukemia/lymphoma 2 related protein A1d; BCL2 related protein A1; Bcl2a1; Bcl2a1a; Bcl2a1d; BCL2L5; bcl2-L-5; Bcl-2-like protein 5; bcl-2-related protein A1; BCL2-related protein A1; BCL2-related protein A1d; Bfl1; Bfl-1; GRS; GRS protein; HBPA1; hematopoietic BCL2-related protein A1; hemopoietic-specific early response protein; Protein BFL-1; Protein GRS
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 12044, 170929, 597
• Content And Storage: 4°C
• Form: Liquid

• Applications: Immunohistochemistry, Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 0.02% sodium azide
• Gene Accession No.: Q07440, Q16548
• Gene Symbols: BCL2A1, Bcl2a1a
• Immunogen: A 14 amino acid peptide from near the amino terminus of human Bfl-1.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov