Invitrogen™ BCL2A1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA524561

Catalog No. PIPA524561

Description

BCL2A1 Polyclonal Antibody for Western Blot, IHC (P), Flow

Bcl-2 related Protein A1 is a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators that are involved in a wide variety of cellular activities such as embryonic development, homeostasis and tumorigenesis. The protein encoded by this gene is able to reduce the release of pro-apoptotic cytochrome c from mitochondria and block caspase activation. This gene is a direct transcription target of NF-kappa B in response to inflammatory mediators, and has been shown to be up-regulated by different extracellular signals, such as granulocyte-macrophage colony-stimulating factor (GM-CSF), CD40, phorbol ester and inflammatory cytokine TNF and IL-1, which suggests a cytoprotective function that is essential for lymphocyte activation as well as cell survival.

Specifications

• Antigen: BCL2A1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: BCL2A1
• Gene Alias: A1; A1-A; ACC1; ACC-1; ACC2; ACC-2; B cell leukemia/lymphoma 2 related protein A1a; BB218357; B-cell leukemia/lymphoma 2 related protein A1; B-cell leukemia/lymphoma 2 related protein A1a; B-cell leukemia/lymphoma 2 related protein A1d; BCL2 related protein A1; Bcl2a1; Bcl2a1a; Bcl2a1d; BCL2L5; bcl2-L-5; Bcl-2-like protein 5; bcl-2-related protein A1; BCL2-related protein A1; BCL2-related protein A1d; Bfl1; Bfl-1; GRS; GRS protein; HBPA1; hematopoietic BCL2-related protein A1; hemopoietic-specific early response protein; Protein BFL-1; Protein GRS
• Host Species: Rabbit
• Purification Method: Ammonium sulfate precipitation, Size-exclusion - Dialysis
• Regulatory Status: RUO
• Gene ID (Entrez): 597
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot
• Concentration: 2 mg/mL
• Formulation: PBS with 0.09% sodium azide; pH 7.4
• Gene Accession No.: Q16548
• Gene Symbols: BCL2A1
• Immunogen: KLH conjugated synthetic peptide between 53-81 amino acids from the central region of human BCL2A1.
• Quantity: 400 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov