BCL2L1 Mouse anti-Human, Clone: OTI2D1, lyophilized, TrueMAB™

Mouse Monoclonal Antibody

Supplier:  OriGene CF506188

Catalog No. 50-166-4221

Description

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

The protein encoded the BCL-X gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Alternative splicing results in multiple transcript variants encoding two different isoforms. The longer isoform acts as an apoptotic inhibitor and the shorter isoform acts as an apoptotic activator.

Specifications

• Antigen: BCL2L1
• Classification: Monoclonal
• Conjugate: Unconjugated
• Gene: BCL2L1
• Gene Alias: BCL-XL/S, BCL2L, BCLX, Bcl-X, PPP1R52
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 598
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Clone: OTI2D1
• Formulation: PBS with 8% trehalose and no preservative; pH 7.3
• Gene Accession No.: Q07817
• Gene Symbols: BCL2L1
• Immunogen: Full length human recombit protein of human BCL2L1 produced in HEK293T cell.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1