Invitrogen™ BCL2L15 Polyclonal Antibody

Catalog No.	Quantity
PA550194	100 μL

Catalog No. PA550194 Supplier Invitrogen™ Supplier No. PA550194

Description

Rabbit Polyclonal Antibody

The antibody detects endogenous levels of total BCL2L15 protein.

Proteins of the Bcl-2 family are critical regulators of apoptosis. Proapoptotic members, like Bax, contain three of the four Bcl-2 homology regions (BH1-3), while BH3-only proteins, like Bim, possess only the short BH3 motif. Database searches revealed Bfk, an unusual novel member of the Bcl-2 family that contains a BH2 and BH3 region but not BH1 or BH4. Bfk is thus most closely related to Bcl-G(L). It lacks a C-terminal membrane anchor and is cytosolic. Enforced expression of Bfk weakly promoted apoptosis and antagonized Bcl-2's prosurvival function. Like Bcl-G(L), Bfk did not bind to any Bcl-2 family members, even though its BH3 motif can mediate association with prosurvival proteins. Low amounts of Bfk were found in stomach, ovary, bone marrow and spleen, but its level in the mammary gland rose markedly during pregnancy, suggesting that Bfk may play a role in mammary development.

Specifications

• Antigen: BCL2L15
• Applications: Immunohistochemistry (Paraffin), Western Blot
• Classification: Polyclonal
• Concentration: 1.4 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 40% glycerol and 0.05% sodium azide; pH 7.4
• Gene: BCL2L15
• Gene Accession No.: Q5TBC7
• Gene Alias: BCL2 like 15; BCL2L15; bcl2-L-15; BCL2-like 15; bcl-2-like protein 15; BCLl2-like 15; Bfk; C1orf178; Gm566; pro-apoptotic Bcl-2 protein; RGD1562344
• Gene Symbols: BCL2L15
• Host Species: Rabbit
• Immunogen: Fusion protein corresponding to a region derived from internal residues of human BCL2-like 15.
• Purification Method: Antigen affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 440603
• Target Species: Human
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG