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Invitrogen™ BCL9L Polyclonal Antibody
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Catalog No. PIPA561946
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100 μL
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PIPA561946 100 μL
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Catalog No. PIPA561946 Supplier Invitrogen™ Supplier No. PA561946
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: MSMCHPGQMS LLGRTGVPPQ QGMVPHGLHQ GVMSPPQGLM TQQNFMLMKQ RGVGGEVYSQ PPHMLSPQGS LMGPPPQQNL MVSHPLRQRS VSLDSQMGYL PAP Highest antigen sequence identity to the following orthologs: Mouse - 98%, Rat - 97%.

Bcl9L, a homolog of Bcl9, was initially identified through a bioinformatics screening. It is expressed in fetal brain, adult lung, eye and prostate, in addition to several types of tumors including pancreatic and prostate cancers. Bcl9L has been shown to interact with beta-catenin, a target of the Wnt signaling pathway, and is required for enhanced beta-catenin-T-cell factor (TCF)-mediated transcription in colorectal tumor cells, possibly by translocating beta-catenin to the nucleus. Other studies have indicated that Bcl9L expression correlates with high nuclear grade cancer phenotype and the expression of ErbB2/HER-2 in breast cancers, suggesting that activity may occur in other types of cancer. Bcl9L has also been shown to be critical for Wnt-mediate regulation of stem cell traits in colon epithelium and adenocarcinomas which are associated with tumor invasion, metastasis, and resistance to therapy.
TRUSTED_SUSTAINABILITY

Specifications

Antigen BCL9L
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 0.1 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene BCL9L
Gene Accession No. Q86UU0
Gene Alias B cell CLL/lymphoma 9-like; B9L; BC003321; B-cell CLL/lymphoma 9-like; B-cell CLL/lymphoma 9-like protein; B-cell lymphoma 9-like protein; BCL9-2; BCL9L; BCL9-like protein; BCL9-related beta-catenin-binding protein; DLNB11; nuclear co-factor of beta-catenin signalling; protein BCL9-2
Gene Symbols BCL9L
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human BCL9L. Recombinant protein control fragment (Product #RP-100464).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 283149
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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