Invitrogen™ BCLAF1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA141680

Catalog No. 01-675-087

Description

PA1-41680 detects BCLAF1 in chimpanzee, canine, human and mouse samples. This antibody is expected to react with chicken and mosquito samples based on sequence homology.

BCLAF1 is an intracellular, death promoting transcriptional repressor of survival genes that interacts with several members of the BCL2 family of proteins. It shows homology to the basic leucine zipper (bzip) and MYB DNA binding domains.From recent research it can be concluded that in case of apoptotic cells this protein localizes to dot-like structures throughout the nucleus, and redistributes to a zone near the nuclear envelope. When over expressed this protein induces apoptosis and can be suppressed by co-expression of BCL2 proteins. Also known as BTF, it triggers a proapoptotic signal, potentially helpful to overcome the resistance to STI571.BCLAF1 is found to express mostly in skeletal muscles.

Specifications

• Antigen: BCLAF1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: BCLAF1
• Gene Alias: 2610102K23Rik; 2700025J07Rik; 2810454G14Rik; 5730534O06Rik; Aa2-041; AI450190; AW556225; BCL2 associated transcription factor 1; bcl-2-associated transcription factor 1; BCL2-associated transcription factor 1; Bcl-2-associated transcription factor 1-like protein; BCLAF1; BCLAF1 and THRAP3 family member 1; bK211L9.1; BP-1; BTF; Btf-s; KIAA0164; mKIAA0164
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 483999, 72567, 9774
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 0.5 mg/mL
• Formulation: PBS with 0.2% gelatin and 0.05% sodium azide
• Gene Accession No.: Q8K019, Q9NYF8
• Gene Symbols: BCLAF1
• Immunogen: Synthetic peptide corresponding to residues 700-750 of humanBCLAF1.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Canine, Monkey
• Product Type: Antibody
• Isotype: IgG