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BCoR Rabbit anti-Human, Polyclonal, Bethyl Laboratories

Catalog No. 501560966
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50-156-0966 100 μL
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Catalog No. 50-156-0966 Supplier Bethyl Laboratories, Inc Supplier No. A301672A
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Description

Rabbit Polyclonal Antibody

The recommended shelf life for this product is 1 year from date of receipt.

Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence-specific DNA-binding proteins such as BCL6 and MLLT3. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor. Involved in the repression of TFAP2A; impairs binding of BCL6 and KDM2B to TFAP2A promoter regions. Via repression of TFAP2A acts as a negative regulator of osteo-dentiogenic capacity in adult stem cells; the function implies inhibition of methylation on histone H3 ′Lys-4′ (H3K4me3) and ′Lys-36′ (H3K36me2). {ECO:0000269; PubMed:10898795, ECO:0000269; PubMed:15004558, ECO:0000269; PubMed:18280243, ECO:0000269; PubMed:19578371, ECO:0000269; PubMed:23911289}.

Specifications

Antigen BCoR
Applications Immunoprecipitation
Classification Polyclonal
Concentration 1 mg/ml
Conjugate Unconjugated
Formulation phosphate, tris citrate with 0.09% sodium azide; pH 7-8
Gene BCOR
Gene Accession No. Q6W2J9
Gene Alias ANOP2, MAA2, MCOPS2, BCL-6 corepressor, BCL-6 interacting corepressor, BCL6 co-repressor
Gene Symbols BCOR
Host Species Rabbit
Immunogen Between 25 and 75
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 54880
Target Species Human
Content And Storage 4° C
Product Type Antibody
Form Liquid
Isotype IgG
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