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Invitrogen™ BCR-ABL Monoclonal Antibody (7C6)
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Catalog No. PIMA1153
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100 μg
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Catalog No. Quantity
PIMA1153 100 μg
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Catalog No. PIMA1153 Supplier Invitrogen™ Supplier No. MA1153
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Description

Mouse Monoclonal Antibody

Western blot analysis of MA1-153 detects ~130-160 kDa and a 210-250 kDa protein in K562 cells. In addition to BCR-ABL, BCR and ABL are also expressed in these cells and full length BCR is also detected by the antibody. For detection purposes, non-reducing conditions resulted in enhanced detection of BCR-ABL.

A reciprocal translocation between chromosomes 22 and 9 produces the BCR-ABL fusion oncoprotein, which is found in patients with chronic myelogenous leukemia (CML). Although there are various versions, p210 is the most commonly found BCR-ABL form. The fusion to BCR, results in deregulated/constitutively active tyrosine kinase activity of BCR-ABL which is sufficient of oncogenic transformation of myeloid cells. Inhibition of BCR-ABL oncogenic activity by the ABL-kinase inhibitor STI-571 (also known as gleevec, imatinib) became the first and best example for successful targeted therapy of cancer, and specifically CML. In recent years, several mutations (such as the T351I mutation) were found in CML patients that resulted in STI-571 resistance and the need for additional drug development.
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Specifications

Antigen BCR-ABL
Applications Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot, Immunocytochemistry
Classification Monoclonal
Clone 7C6
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 1mg/mL BSA and 0.05% sodium azide
Gene BCR
Gene Accession No. P11274, Q6PAJ1
Gene Alias 5133400C09Rik; AI561783; AI853148; ALL; BCR; BCR, RhoGEF and GTPase activating protein; BCR/FGFR1 chimera protein; BCR1; breakpoint cluster region; breakpoint cluster region homolog; breakpoint cluster region protein; CML; D22S11; D22S662; FGFR1/BCR chimera protein; Kiaa3017; mKIAA3017; PHL; Renal carcinoma antigen NY-REN-26
Gene Symbols BCR
Host Species Mouse
Immunogen Bcr686 thyroglobulin conjugate corresponding to human BCR sequence 686-696 (SSINEEITPRRQS).
Purification Method Protein A
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 110279, 613
Target Species Human, Mouse
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG2a
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