Invitrogen™ Beclin 1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5120521

Catalog No. PIPA5120521

Description

Positive test controls include: 293T, Mouse lung, Mouse testis, Rat lung, Rat ovary. The target is usually found in the following locations: Cytoplasm, Cytoplasmic vesicle, Endoplasmic reticulum membrane, Endosome, Endosome membrane, Golgi apparatus, Mitochondrion, Mitochondrion membrane, Nucleus, Peripheral membrane protein, autophagosome, trans-Golgi network membrane. Immunogen sequence: LKLDTSFKIL DRVTIQELTA PLLTTAQAKP GETQEEETNS GEEPFIETPR QDGVSRRFIP PARMMSTESA NSFTLIGEAS DGGTMENLSR RLKVTGDLFD IMSGQTDVDH PLCEECTDTL LDQLDTQLNV TENECQNYKR CLEILEQMNE DDSEQLQMEL KELALEEERL IQELEDVEKN RKIVAENLEK VQAEAERLDQ EEAQYQREYS EFKRQQLELD DELKSVENQM RYAQTQLDKL KKTNVFNATF HIWHSG.

Beclin 1 plays a central role in autophagy. It acts as a core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate. Different PI3K complex forms are believed to play a role in multiple membrane trafficking pathways - PI3KC3-C1 is involved in the initation of autophagosomes and PI3KC3-C2 is involved in the maturation of autophagosomes and endocytosis. Beclin 1 also plays a role in antiviral host defense.

Specifications

• Antigen: Beclin 1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: BECN1
• Gene Alias: 4921513J16Rik; 5430417M23Rik; APG6; Atg6; ATG6 autophagy related 6 homolog; Bcl-2-interacting protein beclin; beclin 1; beclin 1 (coiled-coil, moesin-like BCL2-interacting protein); beclin 1 (coiled-coil, myosin-like BCL2 interacting protein); beclin 1 (coiled-coil, myosin-like BCL2-interacting protein); beclin 1, autophagy related; beclin1; beclin-1; Beclin-1; beclin-1; Beclin-1-C 35 kDa; Beclin-1-C 37 kDa; becn1; Coiled-coil myosin-like BCL2-interacting protein; coiled-coil, myosin-like BCL2-interacting protein; GT197; hypothetical protein MGC73097; myosin-like BCL2 interacting protein; Protein GT197; testis secretory sperm-binding protein Li 215e; VPS30; zgc:73097
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 114558, 56208, 8678
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 2.34 mg/mL
• Formulation: PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
• Gene Accession No.: O88597, Q14457, Q91XJ1
• Gene Symbols: BECN1
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 25-280 of human Beclin 1 (NP_0037571).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG