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Invitrogen™ Bedinvetmab Recombinant Canine Monoclonal Antibody
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Catalog No. PIMA542252
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100 μg
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PIMA542252 100 μg
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Catalog No. PIMA542252 Supplier Invitrogen™ Supplier No. MA542252
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Description

Canine Recombinant Monoclonal Antibody

Endotoxin level < 0.01EU/μg by LAL method Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 °C for one week. Store at -20 to -80 °C for twelve months from the date of receipt.

Bedinvetmab is a biosimilar that targets NGF. Nerve growth factor (NGF) influences the survival and differentiation of a variety of neuronal and nonneuronal cells. The actions of this polypeptide result from binding to specific cell surface receptors which are present as both high and low affinity sites. Although both types of receptor bind NGF only the high affinity form is capable of signal transduction. Cross-linking studies with 125I-NGF have shown that the high affinity receptor of rat PC12 cells forms an Mr 158,000 complex with NGF while the low affinity receptor forms an Mr 100,000 complex. Full length cDNA clones for both the human and rat NGF receptor genes have been produced and sequenced, revealing greater than 90% homology between the two species. NGF exhibits nerve growth stimulating activity and is involved in the regulation of growth and the differentiation of sympathetic and certain sensory neurons. Further, NGF stimulates division and differentiation of sympathetic and embryonic sensory neurons. Mutations in the NGF gene have been associated with hereditary sensory and autonomic neuropathy, type 5 (HSAN5), and dysregulation of NGF gene expression is associated with allergic rhinitis.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Bedinvetmab
Applications ELISA, SDS-Page
Classification Recombinant Monoclonal
Concentration 2.9 mg/mL
Conjugate Unconjugated
Formulation PBS with no preservative; pH 7.5
Gene Alias ZTS-00508841
Host Species Canine
Immunogen Canine (Canis lupus familiaris) NGF/NGFB.
Purification Method Protein A/G
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Target Species Canine
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG2 λ
Target Molecule Chemical
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