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  5. Tocris Bioscience™ Belinostat

Tocris Bioscience™ Belinostat
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Catalog No. 798150
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Quantity:
10 mg
50 mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

Potent pan-HDAC inhibitor

Belinostat is a potent pan-HDAC inhibitor (IC50 = 28 nM). Dose-dependently reduces tumor volume in a rat model of glioblastoma and induces 70% and 28% apoptosis in LN-229 and LN-18 glioma cell lines (IC50 values are 210 nM and 300 nM respectively). In H358 cells, Belinostat dose-dependently reduces cell viability and upregulates amino acids and metabolites of the TCA and urea cycle. Also potently inhibits C4 release from stem cell-derived astrocytes and shows antidepressant activity. Belinostat is brain penetrant.

Specifications

Chemical Name or Material (2E)-N-Hydroxy-3-[3-[(phenylamino)sulfonyl]phenyl]-2-propenamide
CAS 866323-14-0
Quantity 50 mg
Target Histone Deacetylase Inhibitors
Molecular Formula C15H14N2O4S
Purity 98%
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