Beta-2-adaptin Polyclonal Antibody, Bethyl Laboratories

Rabbit Polyclonal Antibody

Catalog Number	Mfr. No.	Quantity
50-156-8483	Bethyl Laboratories, Inc A304719AT	20 μL

Description

The recommended shelf life for this product is 1 year from date of receipt. Based on 100% sequence identity, this antibody is predicted to react with Rat and Bovine

Clathrin-mediated endocytosis is the pathway by which many receptors for nutrients and hormones are internalized to be recycled or down-regulated. During formation of clathrin coated membranes, clathrin co-assembles with heterotetrameric molecules known as assembly polypeptides (APs) or adaptors which form a layer of protein coat between the clathrin lattice and the membrane. There are two characterized adaptors AP1 and AP2. AP1 is associated with clathrin coated vesicles at the trans-Golgi network and AP2 is associated with the endocytic clathrin coated vesicles at the plasma membrane and has been shown to specifically interact with Shc and EGF receptor. AP2 is composed of four subunits, two separate ∼100 kDa gene products with similar domain structures (alpha and beta adaptin) and a ∼50 and ∼17 kDa subunit. There are two alpha-adaptin genes, alpha A and alpha C which have a tissue specific pattern of expression.

Specifications

• Antigen: Beta-2-adaptin
• Classification: Polyclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: TBS with 0.1% BSA and 0.09% sodium azide
• Gene Alias: AP-2 complex subunit beta-1, Adapter-related protein complex 2 beta-1 subunit
• Immunogen: Between 575 and 625
• Primary or Secondary: Primary
• Content And Storage: 4° C
• Gene: AP2B1

• Applications: Western Blot
• Conjugate: Unconjugated
• Host Species: Rabbit
• Target Species: Human, Mouse
• Gene Accession No.: P63010, Q9DBG3
• Gene ID (Entrez): 163, 71770
• Isotype: IgG
• Purification Method: Antigen affinity chromatography
• Product Type: Antibody