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Beta-2-adaptin Rabbit anti-Human, Mouse, Polyclonal, Bethyl Laboratories

Catalog No. 501568481
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50-156-8481 100 μL
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Catalog No. 50-156-8481 Supplier Bethyl Laboratories, Inc Supplier No. A304719A
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Rabbit Polyclonal Antibody

The recommended shelf life for this product is 1 year from date of receipt. Based on 100% sequence identity, this antibody is predicted to react with Rat and Bovine

Clathrin-mediated endocytosis is the pathway by which many receptors for nutrients and hormones are internalized to be recycled or down-regulated. During formation of clathrin coated membranes, clathrin co-assembles with heterotetrameric molecules known as assembly polypeptides (APs) or adaptors which form a layer of protein coat between the clathrin lattice and the membrane. There are two characterized adaptors AP1 and AP2. AP1 is associated with clathrin coated vesicles at the trans-Golgi network and AP2 is associated with the endocytic clathrin coated vesicles at the plasma membrane and has been shown to specifically interact with Shc and EGF receptor. AP2 is composed of four subunits, two separate ∽100 kDa gene products with similar domain structures (alpha and beta adaptin) and a ∽50 and ∽17 kDa subunit. There are two alpha-adaptin genes, alpha A and alpha C which have a tissue specific pattern of expression.

Specifications

Antigen Beta-2-adaptin
Applications Immunoprecipitation, Western Blot
Classification Polyclonal
Concentration 1 mg/ml
Conjugate Unconjugated
Formulation phosphate, tris citrate with 0.09% sodium azide; pH 7-8
Gene AP2B1
Gene Accession No. P63010, Q9DBG3
Gene Alias AP-2 complex subunit beta-1, Adapter-related protein complex 2 beta-1 subunit
Gene Symbols Ap2b1
Host Species Rabbit
Immunogen Between 575 and 625
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 163, 71770
Target Species Human, Mouse
Content And Storage 4° C
Product Type Antibody
Form Liquid
Isotype IgG
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