Invitrogen™ beta-2 Defensin Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA545065

Catalog No. PIPA545065

Description

Peptide sequence: LLFSFLFIFL MPLPGVFGGI GDPVTCLKSG AICHPVFCPR RYKQIGTCGL Sequence homology: Human: 100%.

Defensins (alpha and beta) are cationic peptides with a broad spectrum of antimicrobial activity that comprise an important arm of the innate immune system. The alpha-defensins are distinguished from the beta-defensins by the pairing of their three disulfide bonds. To date, six human beta-defensins have been identified; BD-1, BD-2, BD-3, BD-4, BD-5 and BD-6. beta-defensins are expressed on some leukocytes and at epithelial surfaces. In addition to their direct antimicrobial activities, they can act as chemoattractants towards immature dendritic cells and memory T cells. The beta-defensin proteins are expressed as the C-terminal portion of precursors, and are released by proteolytic cleavage of a signal sequence and, in some cases, a propeptide sequence. Beta-defensins contain a six-cysteine motif that forms three intra-molecular disulfide bonds.

Specifications

• Antigen: beta-2 Defensin
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: DEFB4A
• Gene Alias: BD-2; beta defensin 2; beta defensin-2; Beta-defensin 2; Beta-defensin 4A; DEFB102; DEFB2; DEFB-2; DEFB4; DEFB4A; DEFB4B; Defensin beta 2; defensin beta 4A; Defensin beta2; defensin, beta 2; defensin, beta 4; defensin, beta 4A; Defensin-beta2; HBD-2; SAP1; Skin-antimicrobial peptide 1
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 1673
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Western Blot
• Concentration: 0.5 mg/mL
• Formulation: PBS with 2% sucrose and 0.09% sodium azide
• Gene Accession No.: O15263
• Gene Symbols: DEFB4A
• Immunogen: Synthetic peptide directed towards the N-terminal of human DEFB4A (aa 6-55).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov