Invitrogen™ beta-2 Microglobulin Monoclonal Antibody (9-E10-C6)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ KSK0030102

Catalog No. KSK0030102

Description

KSK 003-01-02 reacts with free as well as MHC class I associated b2-microglobulin from the genus Caiman. KSK 003-01-02 has been successfully used in immunohistochemistry and Western blotting techniques. KSK 003-01-02 is suitable for Western blotting, flow cytometry, immunoprecipitation, and affinity purification on caiman b2-microglobulin. KSK 003-01-02 reacts with a non-polymorphic epitope on caiman b2-microglobulin. NOTE: Concentration is lot-dependent and can vary from 0.85-1.15 mg/mL.

Beta-2-microglobulin (B2M) is a 12-14 kDa protein that is a subunit of the major histocompatibility complex (MHC) class I. Human beta 2 Microglobulin associated with HLA Class I antigens are expressed on many types of cells including lymphocytes, thymocytes, monocytes, granulocytes, platelets, endothelial cells, and epithelial cells, but is absent on erythrocytes. Beta-2 microglobulin is also found in free form in the plasma. The amino acid sequence of Beta-2-microglobulin is homologous to the constant regions of immunoglobulin heavy and light chains, with a predominantly beta pleated sheet structure. The protein is ubiquitously expressed in the cytoplasm, and is involved in antigen processing and presentation. Beta-2-microglobulin also plays a role in TCR signaling, and downstream signaling in naive CD8+ cells. Beta 2-microglobulin is encoded by the B2M gene located on chromosome 15. A mutation in the Beta-2-microglobulin gene has been shown to result in hypercatabolic hypoproteinemia. Levels of beta 2 microglobulin can be used to assess renal function in kidney transplant recipients. Beta-2-microglobulin that protein can be used as a prognostic marker for HIV infection.

Specifications

• Antigen: beta-2 Microglobulin
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 15mM sodium azide; pH 7.4
• Host Species: Mouse
• Purification Method: Protein A
• Regulatory Status: RUO
• Target Species: Reptile
• Product Type: Antibody
• Isotype: IgG1 κ

• Applications: Flow Cytometry, Immunoprecipitation, Western Blot
• Clone: 9-E10-C6
• Conjugate: Unconjugated
• Gene Alias: B2m; B2-microglobulin; b2m-W01; b2m-W03; b2m-Z01; b2m-Z02; b2m-Z03; Beta 2 microglobin; Beta 2 microglobulin; beta 2-microglobulin; beta chain of MHC class I molecules; Beta2 microglobulin; beta-2 microglobulin; beta-2 microglobulin preprotein; beta2m; beta2-m; beta-2-microglobin; beta-2-microglobulin; beta-2-microglobulin C-terminal fragment (55 AA); Beta-2-microglobulin form pI 5.3; B-F; CDABP0092; HDCMA22P; IMD43; Lactollin; Ly-m11; MHC Class I; microglobulin beta-2; Orla-B2m
• Immunogen: Recombinant Caiman beta2-microglobulin.
• Quantity: 400 μL
• Primary or Secondary: Primary
• Content And Storage: 4°C, store in dark
• Form: Liquid