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Invitrogen™ beta-2 Microglobulin Monoclonal Antibody (YTH470.5), Biotin
Rat Monoclonal Antibody
Supplier: Invitrogen™ MA517684
Description
MA5-17684 targets Beta 2-microglobulin in FACS and WB applications and shows reactivity with Human samples. The MA5-17684 immunogen is rat monoclonal antibody raised against human lymphocytes.
Beta-2-microglobulin (B2M) is a 12-14 kDa protein that is a subunit of the major histocompatibility complex (MHC) class I. Human beta 2 Microglobulin associated with HLA Class I antigens are expressed on many types of cells including lymphocytes, thymocytes, monocytes, granulocytes, platelets, endothelial cells, and epithelial cells, but is absent on erythrocytes. Beta-2 microglobulin is also found in free form in the plasma. The amino acid sequence of Beta-2-microglobulin is homologous to the constant regions of immunoglobulin heavy and light chains, with a predominantly beta pleated sheet structure. The protein is ubiquitously expressed in the cytoplasm, and is involved in antigen processing and presentation. Beta-2-microglobulin also plays a role in TCR signaling, and downstream signaling in naive CD8+ cells. Beta 2-microglobulin is encoded by the B2M gene located on chromosome 15. A mutation in the Beta-2-microglobulin gene has been shown to result in hypercatabolic hypoproteinemia. Levels of beta 2 microglobulin can be used to assess renal function in kidney transplant recipients. Beta-2-microglobulin that protein can be used as a prognostic marker for HIV infection.
Specifications
beta-2 Microglobulin | |
Monoclonal | |
0.1 mg/mL | |
PBS with 4-5mg/mL BSA and 0.02% sodium azide | |
P61769 | |
B2m | |
Rat monoclonal antibody raised against human lymphocytes. | |
100 μg | |
Primary | |
Human | |
Antibody | |
IgG2b |
Flow Cytometry, Western Blot | |
YTH470.5 | |
Biotin | |
B2m | |
B2m; B2-microglobulin; b2m-W01; b2m-W03; b2m-Z01; b2m-Z02; b2m-Z03; Beta 2 microglobin; Beta 2 microglobulin; beta 2-microglobulin; beta chain of MHC class I molecules; Beta2 microglobulin; beta-2 microglobulin; beta-2 microglobulin preprotein; beta2m; beta2-m; beta-2-microglobin; beta-2-microglobulin; beta-2-microglobulin C-terminal fragment (55 AA); Beta-2-microglobulin form pI 5.3; B-F; CDABP0092; HDCMA22P; IMD43; Lactollin; Ly-m11; MHC Class I; microglobulin beta-2; Orla-B2m | |
Rat | |
Protein G | |
RUO | |
567 | |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
Liquid |
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