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Invitrogen™ beta Adducin Polyclonal Antibody
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Catalog No. PIPA529499
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100 μL
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PIPA529499 100 μL
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Catalog No. PIPA529499 Supplier Invitrogen™ Supplier No. PA529499
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Description

Rabbit Polyclonal Antibody

Recommended positive controls: mouse brain. Predicted reactivity: Mouse (96%), Rat (95%), Rhesus Monkey (100%), Bovine (93%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Adducins are heteromeric proteins composed of different subunits referred to as adducin alpha, beta and gamma. The three subunits are encoded by distinct genes and belong to a family of membrane skeletal proteins involved in the assembly of spectrin-actin network in erythrocytes and at sites of cell-cell contact in epithelial tissues. While adducins alpha and gamma are ubiquitously expressed, the expression of adducin beta is restricted to brain and hematopoietic tissues. Adducin, originally purified from human erythrocytes, was found to be a heterodimer of adducins alpha and beta. Polymorphisms resulting in amino acid substitutions in these two subunits have been associated with the regulation of blood pressure in an animal model of hypertension. Heterodimers consisting of alpha and gamma subunits have also been described. Structurally, each subunit is comprised of two distinct domains. The amino-terminal region is protease resistant and globular in shape, while the carboxy-terminal region is protease sensitive. The latter contains multiple phosphorylation sites for protein kinase C, the binding site for calmodulin, and is required for association with spectrin and actin. Various adducin beta mRNAs, alternatively spliced at 3'end and/or internally spliced and encoding different isoforms, have been described. The functions of all the different isoforms are not known.
TRUSTED_SUSTAINABILITY

Specifications

Antigen beta Adducin
Applications Western Blot
Classification Polyclonal
Concentration 0.92 mg/mL
Conjugate Unconjugated
Formulation 0.1M tris glycine with 10% glycerol and 0.01% thimerosal; pH 7
Gene Add2
Gene Accession No. P35612, Q9QYB8
Gene Alias 2900072M03Rik; ADD2; Add97; ADDB; adducin 2; adducin 2 (beta); adducin beta; adducin-63; beta-ADD; Beta-adducin; erythrocyte adducin subunit beta; snoRNA MBII-396
Gene Symbols Add2
Host Species Rabbit
Immunogen Recombinant protein encompassing a sequence within the center region of human beta Adducin. The exact sequence is proprietary.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 11519, 119
Target Species Human, Mouse
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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