beta-Amyloid 1-42 Mouse anti-Human, Clone: 2C2G5, GenScript™

Mouse Monoclonal Antibody

Supplier:  Genscript Corporation A0156740

Catalog No. 50-273-684

Description

Reconstitute 40 μg lyophilized powder with 80 μl of deionized water (or equivalent) to antibody concentration of 0.5 mg/mL. A number of mutations, identified in the gene encoding the β-amyloid precursor protein (βAPP), have been linked to early-onset Familial Alzheimers Disease. βAPP is cleaved sequentially by the proteolytic enzymes β-secretase and γ-secretase to produce β-amyloid (Aβ) peptides with the Aβ1-42(43) and the Aβ1-40 forms being the most prevalent. Secreted Aβ peptides can bind to scavenger receptors and the receptor for advanced glycation end products. Aβ peptides are degraded either via a reuptake mechanism followed by endosomal degradation or by an extracellular insulin-degrading enzyme. Extracellular accumulation of Aβ leads to formation of aggregates, fibrils, and eventually amyloid deposits called neuritic plaques, a hallmark of Alzheimer's disease. β-amyloid antibodies and peptides have been developed as tools for elucidating the biology of Alzheimers disease.GenScript Human β-Amyloid 1-42 Antibody (2C2G5), mAb, Mouse is produced from the hybridoma resulting from fusion of Sp2/0 myeloma and B-lymphocytes obtained from mouse immunized with a synthetic peptide corresponding to amino acids 36-42 of human β-Amyloid conjugated to KLH (Swiss Prot: P05067).

beta-Amyloid 1-42 Monoclonal antibody specifically detects beta-Amyloid 1-42 in Human samples. It is validated for Dot Blot, ELISA, Immunohistochemistry (Paraffin)

Specifications

• Antigen: beta-Amyloid 1-42
• Classification: Monoclonal
• Conjugate: Unconjugated
• Gene: APP
• Gene Alias: A beta 1 42; A ß 1 42; A4; AAA; AB42; Abeta; Abeta40; Abeta42; ABPP; AD1; Adap; AG; AICD-50; AICD-57; AICD-59; AID(50); AID(57); AID(59); Alpha-CTF; Alpha-secretase C-terminal fragment; Alzheimer disease amyloid A4 protein homolog; alzheimer disease amyloid protein; Amyloid; amyloid A4; Amyloid b; Amyloid beta; amyloid beta (A4) precursor protein; Amyloid beta 1 42; amyloid beta A4 protein; amyloid beta precursor protein; Amyloid intracellular domain 50; Amyloid intracellular domain 57; Amyloid intracellular domain 59; Amyloid precursor protein; Amyloid ß; Amyloid-beta A4 protein; Amyloid-beta precursor protein; Amyloid-beta protein 40; Amyloid-beta protein 42; Amyloidogenic glycoprotein; APP; APP-C57; APP-C59; APP-C99; APPI; appican; Aß 1 42; B APP42; BAPP42; beta-amyloid peptide; beta-amyloid peptide(1-40); beta-amyloid peptide(1-42); beta-amyloid precursor protein; betaApp; Beta-APP40; BetaAPP42; Beta-APP42; Beta-CTF; Beta-secretase C-terminal fragment; C31; C80; C83; C99; Cerebr
• Immunogen: KLH conjugated synthetic peptide derived from human beta-Amyloid 1-42
• Quantity: 40 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

• Applications: Dot Blot, ELISA, Immunohistochemistry (Paraffin)
• Clone: 2C2G5
• Formulation: PBS with 0.02% sodium azide; pH 7.4
• Gene Accession No.: P05067
• Host Species: Mouse
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 351
• Content And Storage: -20°C or -80°C if preferred
• Form: Lyophilized