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Beta-Arrestin 2 Polyclonal Antibody, Bethyl Laboratories

Catalog No. 501566057
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50-156-6057 20 μL
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Catalog No. 50-156-6057 Supplier Bethyl Laboratories, Inc Supplier No. A303786AT
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Description

Rabbit Polyclonal Antibody

The recommended shelf life for this product is 1 year from date of receipt. Application Note: For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections. Based on 100% sequence identity, this antibody is predict

Beta-arrestin-2, or ARRB2, is an adaptor protein belonging to the arrestin family with an N- arrestin domain and a C- arrestin domain. ARRB2 is a regulatory protein involved in heterotrimeric G protein-coupled receptor desensitization and is known to regulate beta2-adrenergic receptor (beta2AR) function by enhancing beta2AR mediated nuclear translocation of ERK. ARRB2 binds to phosphorylated beta2ARs, thereby causing a significant impairment of their capacity to activate G(S) proteins. Along with AIP4, ARRB2 acts as an endosomal sorting molecule that mediates CXCR4 entry into a degradative pathway. It may also be involved in hormone-specific desensitization of TSH receptors. ARRB2 is a Ca2+ binding protein of the retinal outer segments and binds to P-rhodopsin and is also involved in synaptic transmission in photoreceptor cells.It is widely expressed in most of the tissues, especially neuronal tissues and spleen.

Specifications

Antigen Beta-Arrestin 2
Applications Immunohistochemistry, Western Blot
Classification Polyclonal
Conjugate Unconjugated
Formulation TBS with 0.1% BSA and 0.09% sodium azide
Gene ARRB2
Gene Accession No. P32121
Gene Alias beta-arrestin2, SAG, S-Arrestin
Gene Symbols ARRB2
Host Species Rabbit
Immunogen Between 355 and 405
Purification Method Antigen affinity chromatography
Quantity 20 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 409
Target Species Human
Content And Storage 4° C
Product Type Antibody
Form Liquid
Isotype IgG
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