beta-Catenin Antibody - IHC-Prediluted, Novus Biologicals™

Rabbit Polyclonal Antibody

Supplier:  Novus Biologicals NBP248367

Catalog No. NBP248367

Description

beta-Catenin Polyclonal specifically detects beta-Catenin in Human, Mouse samples. It is validated for Immunohistochemistry, Immunohistochemistry-Paraffin.

Specifications

• Antigen: beta-Catenin
• Classification: Polyclonal
• Dilution: Immunohistochemistry-Paraffin
• Gene Alias: beta 1 (88kD), beta-catenin, catenin (cadherin-associated protein), beta 1, 88kDa, catenin beta-1, CTNNB, DKFZp686D02253, FLJ25606, FLJ37923
• Host Species: Rabbit
• Molecular Weight of Antigen: 92 kDa
• Quantity: 7 mL
• Research Discipline: Cancer, Cellular Markers, Extracellular Matrix, Mucosal Immunology, Neuroscience, Stem Cell Signaling Pathway, Wnt Signaling Pathway
• Gene ID (Entrez): 1499
• Target Species: Human, Mouse
• Form: Purified

• Applications: Immunohistochemistry (Paraffin)
• Conjugate: Unconjugated
• Formulation: PBS with 0.05% BSA. with 0.05% Sodium Azide
• Gene Symbols: CTNNB1
• Immunogen: A synthetic peptide from the middle of beta-Catenin protein (Uniprot: P35222)
• Purification Method: Protein A purified
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Test Specificity: Beta-catenin associates with the cytoplasmic portion of E-cadherin, which is necessary for the function of E-cadherin as an adhesion molecule. In normal tissues, beta-catenin is localized to the membrane of epithelial cells, consistent with its role in the cell adhesion complex. In breast ductal neoplasia, beta-catenin is usually localized in cellular membranes. However, in lobular neoplasia, a marked redistribution of beta-catenin throughout the cytoplasm results in a diffuse cytoplasmic pattern. Immuno-staining of beta-catenin and E-cadherin is helps in the accurate identification of ductal and lobular neoplasms, including a distinction between low-grade ductal carcinoma in situ (DCIS) and lobular carcinoma. Additionally, some rectal and gastric adenocarcinomas demonstrate diffuse cytoplasmic beta-catenin staining and a lack of membranous staining, mimicking the staining pattern observed with lobular breast carcinomas.
• Content And Storage: Store at 4C.
• Isotype: IgG