Beta crystallin S Rabbit anti-Human, Polyclonal, Bioss

Catalog No.	Quantity
50-198-2423	100 μL

Catalog No. 50-198-2423 Supplier Bioss Supplier No. BS12860R

Description

Rabbit Polyclonal Antibody

Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Gamma-crystallins are a homogeneous group of highly symmetrical, monomeric proteins typically lacking connecting peptides and terminal extensions. They are differentially regulated after early development. This gene encodes a protein initially considered to be a beta-crystallin but the encoded protein is monomeric and has greater sequence similarity to other gamma-crystallins. This gene encodes the most significant gamma-crystallin in adult eye lens tissue. Whether due to aging or mutations in specific genes, gamma-crystallins have been involved in cataract formation.

Specifications

• Antigen: Beta crystallin S
• Applications: Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
• Classification: Polyclonal
• Concentration: 1 μg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
• Gene: CRYGS
• Gene Accession No.: P22914
• Gene Alias: AI327013; Beta-crystallin S; BOS_907; CRYG8; CRYGS; crystallin gamma S; crystallin, gamma 8; crystallin, gamma polypeptide 8; crystallin, gamma S; CTRCT20; Gamma-crystallin S; Gamma-S-crystallin; gammaS-crystallin; opacity due to poor secondary fiber cell junction; Opj; recessive nuclear cataract; rncat
• Gene Symbols: CRYGS
• Host Species: Rabbit
• Immunogen: KLH conjugated synthetic peptide derived from human Beta crystallin S.
• Purification Method: Protein A
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 1427
• Target Species: Human
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG