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Invitrogen™ beta Dystroglycan Monoclonal Antibody (GT9112)
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Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA535930

Catalog No. PIMA535930


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Description

Description

beta Dystroglycan Monoclonal Antibody for Western Blot, IHC (P)

Dystroglycan is a laminin binding component of the dystrophin-glycoprotein complex which provides a linkage between the subsarcolemmal cytoskeleton and the extracellular matrix. Dystroglycan 1 is a candidate gene for the site of the mutation in autosomal recessive muscular dystrophies. The dramatic reduction of dystroglycan 1 in Duchenne muscular dystrophy leads to a loss of linkage between the sarcolemma and extracellular matrix, rendering muscle fibers more susceptible to necrosis. Dystroglycan also functions as dual receptor for agrin and laminin-2 in the Schwann cell membrane. The muscle and nonmuscle isoforms of dystroglycan differ by carbohydrate moieties but not protein sequence. Alternative splicing results in multiple transcript variants all encoding the same protein.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

beta Dystroglycan
Monoclonal
1 mg/mL
PBS with 20% glycerol and no preservative
Q14118, Q62165
DAG1
Recombinant protein encompassing a sequence within the Extracellular domain of human DAG1/beta Dystroglycan. The exact sequence is proprietary.
100 μL
Primary
Human, Mouse
Antibody
IgG1
Immunohistochemistry (Paraffin), Western Blot
GT9112
Unconjugated
DAG1
156DAG; A3a; AGRNR; Alpha-DG; Alpha-dystroglycan; Beta-DG; Beta-dystroglycan; D9Wsu13e; DAG; DAG1; Dag-1; DG; Dp427; Dp71; dystroglycan; dystroglycan 1; dystroglycan 1 (dystrophin-associated glycoprotein 1); dystrophin associated glycoprotein 1; Dystrophin-associated glycoprotein 1; MDDGA9; MDDGC7; MDDGC9
Mouse
Protein G
RUO
13138, 1605
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Liquid
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