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Invitrogen™ beta Dystroglycan Monoclonal Antibody (GT9112)
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Catalog No. PIMA535930
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100 μL
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PIMA535930 100 μL
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Catalog No. PIMA535930 Supplier Invitrogen™ Supplier No. MA535930
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Description

Mouse Monoclonal Antibody

beta Dystroglycan Monoclonal Antibody for Western Blot, IHC (P)

Dystroglycan is a laminin binding component of the dystrophin-glycoprotein complex which provides a linkage between the subsarcolemmal cytoskeleton and the extracellular matrix. Dystroglycan 1 is a candidate gene for the site of the mutation in autosomal recessive muscular dystrophies. The dramatic reduction of dystroglycan 1 in Duchenne muscular dystrophy leads to a loss of linkage between the sarcolemma and extracellular matrix, rendering muscle fibers more susceptible to necrosis. Dystroglycan also functions as dual receptor for agrin and laminin-2 in the Schwann cell membrane. The muscle and nonmuscle isoforms of dystroglycan differ by carbohydrate moieties but not protein sequence. Alternative splicing results in multiple transcript variants all encoding the same protein.
TRUSTED_SUSTAINABILITY

Specifications

Antigen beta Dystroglycan
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Monoclonal
Clone GT9112
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 20% glycerol and no preservative
Gene DAG1
Gene Accession No. Q14118, Q62165
Gene Alias 156DAG; A3a; AGRNR; Alpha-DG; Alpha-dystroglycan; Beta-DG; Beta-dystroglycan; D9Wsu13e; DAG; DAG1; Dag-1; DG; Dp427; Dp71; dystroglycan; dystroglycan 1; dystroglycan 1 (dystrophin-associated glycoprotein 1); dystrophin associated glycoprotein 1; Dystrophin-associated glycoprotein 1; MDDGA9; MDDGC7; MDDGC9
Gene Symbols DAG1
Host Species Mouse
Immunogen Recombinant protein encompassing a sequence within the Extracellular domain of human DAG1/beta Dystroglycan. The exact sequence is proprietary.
Purification Method Protein G
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 13138, 1605
Target Species Human, Mouse
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG1
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