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Invitrogen™ beta Dystroglycan Polyclonal Antibody
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Catalog No. PIPA519731
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100 μg
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Catalog No. Quantity
PIPA519731 100 μg
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Catalog No. PIPA519731 Supplier Invitrogen™ Supplier No. PA519731
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Description

Rabbit Polyclonal Antibody

This antibody is predicted to react with mouse, rabbit, cow and dog based on sequence homology.

Dystroglycan is a laminin binding component of the dystrophin-glycoprotein complex which provides a linkage between the subsarcolemmal cytoskeleton and the extracellular matrix. Dystroglycan 1 is a candidate gene for the site of the mutation in autosomal recessive muscular dystrophies. The dramatic reduction of dystroglycan 1 in Duchenne muscular dystrophy leads to a loss of linkage between the sarcolemma and extracellular matrix, rendering muscle fibers more susceptible to necrosis. Dystroglycan also functions as dual receptor for agrin and laminin-2 in the Schwann cell membrane. The muscle and nonmuscle isoforms of dystroglycan differ by carbohydrate moieties but not protein sequence. Alternative splicing results in multiple transcript variants all encoding the same protein.
TRUSTED_SUSTAINABILITY

Specifications

Antigen beta Dystroglycan
Applications Western Blot
Classification Polyclonal
Concentration 0.9 mg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA and 0.02% sodium azide; pH 7.4
Gene DAG1
Gene Accession No. Q14118
Gene Alias 156DAG; A3a; AGRNR; Alpha-DG; Alpha-dystroglycan; Beta-DG; Beta-dystroglycan; D9Wsu13e; DAG; DAG1; Dag-1; DG; Dp427; Dp71; dystroglycan; dystroglycan 1; dystroglycan 1 (dystrophin-associated glycoprotein 1); dystrophin associated glycoprotein 1; Dystrophin-associated glycoprotein 1; MDDGA9; MDDGC7; MDDGC9
Gene Symbols DAG1
Host Species Rabbit
Immunogen Synthetic peptide conjugated to KLH derived from within residues 650 - 750 of Human Dystroglycan precursor.
Purification Method Antigen Affinity Chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 1605
Target Species Human
Content And Storage -20°C or -80°C if preferred
Product Type Antibody
Form Liquid
Isotype IgG
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