Tocris Bioscience™ beta-GalNAc-PEG4-Azide

Description

Asialoglycoprotein receptor ligand with PEG4 linker and azide group for onward chemistry

β-GalNAc-PEG4-Azide is a functionalized asialoglycoprotein receptor (ASGPR) ligand for lysosomal targeting chimera (LYTAC) research and development; incorporates a single ASGPR ligand with a PEG4 linker and azide group reactive handle ready for conjugation. It can be used as a building block for multivalent compounds to enhance ASGPR binding. Upon binding to ASGPR, β-GalNAc conjugates are efficiently internalized via ASGPR-mediated endocytosis. β-GalNAc conjugation can be employed as a strategy to effectively deliver cargo such as RNA or Cas9 complexes in a cell-specific manner to hepatocytes. Can be used to generate LYTACs, or labeled with dye for tissue imaging.

Specifications

• Chemical Name or Material: 2-[2-[2-(2-Azidoethoxy)ethoxy]ethoxy]ethyl 2-(acetylamino)-2-deoxy-β-D-galactopyranoside
• CAS: 879004-92-9
• Quantity: 25 mg
• Target: ASGPR1
• Molecular Formula: C₁₆H₃₀N₄O₉