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beta-NGF Polyclonal Antibody, Biotin, PeproTech®, Invitrogen™

Rabbit Polyclonal Antibody

$319.00 - $2175.00

Specifications

Antigen beta-NGF
Concentration 0.1-1.0 mg/mL
Applications ELISA, Western Blot
Classification Polyclonal
Conjugate Biotin
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Products 2
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
500P85BT50
Encompass_Preferred
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Invitrogen™
500P85BT50UG
50 μg
Each for $319.00
Only null left
Add to Cart
 
50-271-8441
Encompass_Preferred
View Documents
Invitrogen™
500P85BT500UG
500 μg
Each for $2,175.00
Only null left
Add to Cart
 
Description

Description

AA Sequence of recombinant protein: SSSHPIFHRG EFSVCDSVSV WVGDKTTATD IKGKEVMVLG EVNINNSVFK QYFFETKCRD PNPVDSGCRG IDSKHWNSYC TTTHTFVKAL TMDGKQAAWR FIRIDTACVC VLSRKAVRRA. Preparation: Produced from sera of rabbits immunized with highly pure Recombinant Human beta-NGF. Anti-Human beta-NGF-specific antibody was purified by affinity chromatography and then biotinylated. Sandwich ELISA: To detect Human beta-NGF by sandwich ELISA (using 100 μL/well antibody solution) a concentration of 0.25-1.0 μg/mL of this antibody is required. This biotinylated polyclonal antibody, in conjunction with PeproTech Polyclonal Anti-Human beta-NGF (500-P85) as a capture antibody, allows the detection of at least 0.2-0.4 ng/well of Recombinant Human beta-NGF. Western Blot: To detect Human beta-NGF by Western Blot analysis this antibody can be used at a concentration of 0.1-0.2 μg/mL. When used in conjunction with compatible secondary reagents, the detection limit for Recombinant Human beta-NGF is 1.5-3.0 ng/lane, under either reducing or non-reducing conditions. 500-P85BT-1MG will be provided as 2 x 500 μg

Nerve growth factor (NGF) influences the survival and differentiation of a variety of neuronal and nonneuronal cells. The actions of this polypeptide result from binding to specific cell surface receptors which are present as both high and low affinity sites. Although both types of receptor bind NGF only the high affinity form is capable of signal transduction. Cross-linking studies with 125I-NGF have shown that the high affinity receptor of rat PC12 cells forms an Mr 158,000 complex with NGF while the low affinity receptor forms an Mr 100,000 complex. Full length cDNA clones for both the human and rat NGF receptor genes have been produced and sequenced, revealing greater than 90% homology between the two species. NGF exhibits nerve growth stimulating activity and is involved in the regulation of growth and the differentiation of sympathetic and certain sensory neurons. Further, NGF stimulates division and differentiation of sympathetic and embryonic sensory neurons. Mutations in the NGF gene have been associated with hereditary sensory and autonomic neuropathy, type 5 (HSAN5), and dysregulation of NGF gene expression is associated with allergic rhinitis.
Specifications

Specifications

beta-NGF
ELISA, Western Blot
Biotin
Rabbit
Human
P01138
4803
E.coli-derived, 27.0 kDa Recombinant Human beta-NGF.
Antigen Affinity Chromatography
NGF
0.1-1.0 mg/mL
Polyclonal
Lyophilized
RUO
PBS with no preservative
B nerve growth factor; beta ngf; beta-nerve growth factor; BetaNGF; beta-NGF; bNGF; b-NGF; HSAN5; MGC161426; MGC161428; Nerve growth factor; nerve growth factor (beta polypeptide); nerve growth factor, beta; nerve growth factor, beta polypeptide; nerve growth factor, beta subunit; NGF; NGF b; NGF ß; Ngfb; NGFbeta; NGFß; ß nerve growth factor; ß NGF; ßNGF
NGF
Primary
-20°C
Videos
SDS
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Documents

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