Invitrogen™ beta Synuclein Monoclonal Antibody (6A10)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA547455

Catalog No. PIMA547455

Description

beta Synuclein Monoclonal Antibody for Western Blot, ICC/IF, IHC (PFA)

Synuclein family of proteins is abundantly expressed in neuronal cytosol and presynaptic terminals. In vertebrates they are encoded by three different genes. Synucleins have been specifically implemented in three major diseases: Alzheimer's (AD), Parkinson's PD) and breast cancer. In AD, a peptide derived from alpha synuclein forms an intrinsic component of plaque amyloid. In PD, an alpha synuclein accumulates in Lewy bodies. An allele of alpha synuclein has been linked to many familial cases of PD. In breast cancer increased expression of gamma synuclein correlates with the disease progression. Synucleins appear to be involved in the membrane plasticity in developing song control system of songbirds.

Specifications

• Antigen: beta Synuclein
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 5mM sodium azide
• Gene Accession No.: P33567, Q16143, Q63754, Q91ZZ3
• Gene Symbols: SNCB
• Immunogen: C-terminal peptide of human beta-synuclein EPEGESYEDPPQEEYQEYEPEA coupled to KLH.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat, Bovine, Pig
• Product Type: Antibody
• Isotype: IgG1

• Applications: Immunohistochemistry (PFA fixed), Western Blot, Immunocytochemistry
• Clone: 6A10
• Conjugate: Unconjugated
• Gene: SNCB
• Gene Alias: AI838531; betaSYN; beta-synuclein; Phosphoneuroprotein 14; PNP 14; Sncb; synuclein beta; synuclein, beta
• Host Species: Mouse
• Purification Method: Protein A/G
• Regulatory Status: RUO
• Gene ID (Entrez): 100127169, 104069, 113893, 508421, 6620
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov