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Invitrogen™ beta Synuclein Polyclonal Antibody
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Catalog No. PIPA587902
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100 μL
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PIPA587902 100 μL
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Catalog No. PIPA587902 Supplier Invitrogen™ Supplier No. PA587902
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: MDVFMKGLSM AKEGVVAAAE KTKQGVTEAA EKTKEGVLYV GSKTREGVVQ GVASVAEKTK EQASHLGGAV FSGAGNIAAA TGLVKREEFP TDLKPEEVAQ EAAEEPLIEP LMEPEGESYE DPPQEEYQEY EPEA; Positive Samples: Mouse eye, Mouse brain, Rat brain, Rat spinal cord; Cellular Location: Cytoplasm.

Synuclein family of proteins is abundantly expressed in neuronal cytosol and presynaptic terminals. In vertebrates they are encoded by three different genes. Synucleins have been specifically implemented in three major diseases: Alzheimer's (AD), Parkinson's PD) and breast cancer. In AD, a peptide derived from alpha synuclein forms an intrinsic component of plaque amyloid. In PD, an alpha synuclein accumulates in Lewy bodies. An allele of alpha synuclein has been linked to many familial cases of PD. In breast cancer increased expression of gamma synuclein correlates with the disease progression. Synucleins appear to be involved in the membrane plasticity in developing song control system of songbirds.
TRUSTED_SUSTAINABILITY

Specifications

Antigen beta Synuclein
Applications ELISA, Western Blot
Classification Polyclonal
Concentration 1.01 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene SNCB
Gene Accession No. Q63754, Q91ZZ3
Gene Alias AI838531; betaSYN; beta-synuclein; Phosphoneuroprotein 14; PNP 14; Sncb; synuclein beta; synuclein, beta
Gene Symbols SNCB
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-134 of human beta-Synuclein (NP_0010015021).
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 104069, 113893
Target Species Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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